School of Medicine researchers and their collaborators have created a powerful new tool they say will benefit essentially every area of biomedical research, from understanding how healthy cells function to the battle against cancer and neurodegenerative diseases such as Alzheimer’s. Gloria M. Sheynkman, PhD, an assistant professor in the Department of Molecular Physiology and Biological Physics and her team have developed a new and better way to identify proteins our genes make. Better understanding these proteins will help scientists unlock the mysteries of how our cells work and how diseases take hold, and targeting the proteins could lead to important new treatments for a wide variety of conditions. Sheynkman’s new tool to understand the proteins takes a two-pronged approach, combining mass spectrometry data with a technology called long-read RNA sequencing that is used to predict isoforms.
Researchers published their findings in the scientific journal Genome Biology, which was recently highlighted in Nature Methods.