Sana Syed, MD, MSCR, MSDS, an associate professor in the School of Medicine’s Department of Pediatrics, was recently awarded an R01 grant from the NIH providing $2,739,706 in funding to predict future outcomes of Crohn’s disease to improve clinical treatment for children. This award pulls together a star team of highly-regarded investigators across the UVA School of Medicine including Chris Moskaluk, MD, PhD, Shyam Raghavan, MD, Robin Legallo, MD, and Anne Tuskey, MD; UVA School of Data Science Professor Don Brown, PhD; and Emory University researchers Subra Kugathasan, MD, Jason Matthews, PhD, and David Cutler, PhD.
By using state-of-the-art machine learning approaches to identify tissue features associated with the development of future disease progression, Dr. Syed and her collaborators aim to build machine learning models capable of predicting patient-specific outcomes of Crohn’s disease at the time of initial diagnosis. In parallel, the team will create a genomic profile of Crohn’s disease at a single-cell resolution to reveal underlying changes associated with disease. Together, this study will establish a foundation for personal precision medicine and significant impact the lives of patients living with this debilitating chronic disease.
Reviewers highlighted the need for pediatric-focused research, the potential impact of the innovative project, and the excellent reputations of the investigators and supporting institutions.
Read more about Dr. Syed’s research: https://med.virginia.edu/sana-syed-lab/