Cardiovascular Medicine Professor Kenneth Walsh, MD, PhD, and his team used cutting-edge CRISPR gene-editing technology to develop a special mouse model to better understand the effects of Y chromosome loss in the blood. They found that the loss accelerated age-related diseases, made the mice more prone to heart scarring and led to earlier death. This new research may explain why men die sooner than women, and could lead to longer, healthier lives for men.
The researchers have published their findings in the journal Science. The team consisted of Soichi Sano, Keita Horitani, Hayato Ogawa, Jonatan Halvardson, Nicholas W. Chavkin, Ying Wang, Miho Sano, Jonas Mattisson, Atsushi Hata, Marcus Danielsson, Emiri Miura-Yura, Ammar Zaghlool, Megan A. Evans, Tove Fall, Henry N. De Hoyos, Johan Sundström, Yoshimitsu Yura, Anupreet Kour, Yohei Arai, Mark C. Thel, Yuka Arai, Josyf C. Mychaleckyj, Karen K. Hirschi, Forsberg and Walsh.
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