Helmy Siragy, MD, the Harrison Distinguished Chair of Excellence in Medical Education and professor in the Department of Medicine, Division of Endocrinology and Metabolism, is serving as guest editor for the International Journal of Molecular Sciences’ special issue “The Angiotensin in Human Health and Diseases.” The special issue will focus on the evolving knowledge about renin angiotensin aldosterone system (RAAS) activities in human health and disease. Dr. Siragy invites members of the faculty to submit original research or review manuscripts.
RAAS plays an important role in the control of body fluid and electrolyte homeostasis, as well as in blood pressure regulation. Angiotensin II is the most important effector hormone in this system and functions primarily through the stimulation of its subtype receptors, in particular the AT1 receptor. The knowledge about the involvement of other angiotensin receptors in physiological and pathological processes is still evolving. RAAS contributes to the regulation of cardiovascular, renal and metabolic functions. Additionally, RAAS regulates cellular growth and matrix formation. The imbalance of RAAS function has been linked to multiple cardiovascular, renal and metabolic diseases.
Learn more about submitting a manuscript.