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Medicine Grand Rounds | David A. D’Alessio, MD – Regulation of Insulin Secretion by GI Hormones: Physiology, Pharmacology and Mythology (Crispell Lecture in Endocrinology)

Date: Wednesday June 28, 2017
Time: 12:00 PM until 1:00 PM
Location: Pinn Hall Auditorium (rm 1-5)
Cost: Free


David A. D’Alessio, MD, is a professor of medicine and director of the Division of Endocrinology at Duke University School of Medicine. He also serves as associate director of the Duke Molecular Physiology Institute. Dr. D’Alessio is a physician-scientist and translational investigator with 25 years of experience in human and animal research related to metabolism, obesity and diabetes. His research focuses on regulation of insulin secretion by GI hormones, particularly GLP-1, and the role of incretins in ß-cell function in type 2 diabetes. In recent years, it has expanded to include humans with bariatric surgery, because these individuals have accentuated GLP-1 responses.

His lab is funded through an on-going R01 award, a Merit Award from the V.A., and industry and institutional sources.

Learning objectives:
1. Define the incretin effect.
2. Compare and contrast the two major incretins.
3. Describe the two pharmacologic approaches to using incretin signaling to treat diabetes.


Medicine Grand Rounds is offered every Wednesday throughout the year by the UVA Department of Medicine, in association with UVA’s Office of Continuing Medical Education. CME credit is available; instructions and forms are available at the event.

The University of Virginia School of Medicine is accredited by the ACCME to provide continuing medical education for physicians. The University of Virginia School of Medicine designates this live activity for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only credit commensurate with the extent of their participation in the activity. The University Of Virginia School Of Medicine awards one hour of participation to each non-physician participant who successfully completes this educational activity. The University of Virginia School of Medicine maintains a permanent record of participants who have been awarded hours of participation. CME transcripts may be obtained at www.cmevillage.com (click on Transcripts and follow the instructions).

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