Mark Donowitz, MD
Date: Wednesday, May 24, 2017
Time: 12:00 to 1:00 pm
Location: Pinn Hall auditorium , 1-5
Cost: Free
Mark Donowitz, MD, is the LeBoff Professor of Medicine, Professor of Physiology, and director of the Hopkins Center for Epithelial Disorders at the Johns Hopkins University School of Medicine. He is also the founding director of the NIH/NIDDK Hopkins Conte Digestive Diseases Center for Basic and Translational Research. He has served as president of the American Gastroenterological Association.
He has had a distinguished career of scientific discovery, mentorship of young researchers and advocacy for the gastroenterology specialty. He is a past president of the American Gastroenterological Association, and has also served as president of the Gastroenterology-Research Group. He has received the Distinguished Achievement Award and the Davenport Memorial Prize from the American Physiology Society, and is a fellow of the American Association for the Advancement of Science.
Dr. Donowitz’s scientific focus is understanding regulation of intestinal Na absorption in normal digestive physiology, and abnormalities that contribute to diarrheal diseases. His group was the first to recognize the mammalian Na/H exchanger gene family, to clone the epithelial isoforms, and to trace the evolutionary development of the gene family. He has examined structure/function aspects of the exchangers and identified the large, multiprotein complexes in which the epithelial NHEs function. In addition, his group identified a gene family of PDZ containing brush border proteins called the NHERF family which are scaffolding proteins which interact with NHE3 and are involved in forming the multiprotein complexes, are critical for its regulation, and take part in its association with the cytoskeleton.
His clinical interests are in diagnosis and management of chronic diarrheal diseases, including short gut syndrome, inflammatory bowel diseases and celiac disease.
Learning objectives:
- Learn about human mini-intestines and how they relate to human intestinal stem cells.
- Learn how human mini-intestines can be used to understand IBD and its treatment.
Medicine Grand Rounds is offered every Wednesday throughout the year by the UVA Department of Medicine, in association with UVA’s Office of Continuing Medical Education. CME credit is available; instructions and forms are available at the event.
The University of Virginia School of Medicine is accredited by the ACCME to provide continuing medical education for physicians. The University of Virginia School of Medicine designates this live activity for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only credit commensurate with the extent of their participation in the activity. The University Of Virginia School Of Medicine awards one hour of participation to each non-physician participant who successfully completes this educational activity. The University of Virginia School of Medicine maintains a permanent record of participants who have been awarded hours of participation. CME transcripts may be obtained at www.cmevillage.com (click on Transcripts and follow the instructions).
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