(l-r) Mark Okusa, Tsuyoshi Inoue, Patrice Guyenet, Chikara Abe, Ruth Stornetta and Diane Rosin.
The Okusa research lab, together with colleagues from the Department of Pharmacology — including faculty members Patrice Guyenet and Diane Rosin and former postoc Chikara Abe — published a paper in Nature Neuroscience in March (on-line, ahead of print). Joint first authors were Nephrology post-doc Tsuyoshi Inoue (see his profile in this issue) and former pharmacology postdoc Dr. Abe.
Congratulations to all.
- Abe C, Inoue T*, Inglis MA, Viar KE, Huang L, Ye H, Rosin DL, Stornetta RL, Okusa MD, Guyenet PG. C1 neurons mediate a stress-induced anti-inflammatory reflex in mice. Nature Neuroscience 2017 Mar 13. doi: 10.1038/nn.4526. [Epub ahead of print]
ABSTRACT: C1 neurons, located in the medulla oblongata, mediate adaptive autonomic responses to physical stressors (for example, hypotension, hemorrhage and presence of lipopolysaccharides). We describe here a powerful anti-inflammatory effect of restraint stress, mediated by C1 neurons: protection against renal ischemia-reperfusion injury. Restraint stress or optogenetic C1 neuron (C1) stimulation (10 min) protected mice from ischemia-reperfusion injury (IRI). The protection was reproduced by injecting splenic T cells that had been preincubated with noradrenaline or splenocytes harvested from stressed mice. Stress-induced IRI protection was absent in Chrna7 knockout (a7nAChR−/−) mice and greatly reduced by destroying or transiently inhibiting C1. The protection conferred by C1 stimulation was eliminated by splenectomy, ganglionic-blocker administration or β2-adrenergic receptor blockade. Although C1 stimulation elevated plasma corticosterone and increased both vagal and sympathetic nerve activity, C1-mediated IRI protection persisted after subdiaphragmatic vagotomy or corticosterone receptor blockade. Overall, acute stress attenuated IRI by activating a cholinergic, predominantly sympathetic, anti-inflammatory pathway. C1s were necessary and sufficient to mediate this effect.
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Tags: Nephrology, Publications