{"id":942,"date":"2018-04-20T16:26:24","date_gmt":"2018-04-20T20:26:24","guid":{"rendered":"https:\/\/news.med.virginia.edu\/fac-dev-blog\/?p=942"},"modified":"2020-02-21T16:36:57","modified_gmt":"2020-02-21T21:36:57","slug":"uva-som-faculty-news-weekly-round-up-april-20-2018","status":"publish","type":"post","link":"https:\/\/news.med.virginia.edu\/fac-dev-blog\/2018\/04\/20\/uva-som-faculty-news-weekly-round-up-april-20-2018\/","title":{"rendered":"UVA SOM Faculty News Weekly Round-Up: April 20, 2018"},"content":{"rendered":"

\"GraphicUVA SOM Faculty News Weekly Round-Up
\nApril 20, 2018<\/p>\n

\u2022 UVA Pediatric Oncologist Honored on Top 10 List of Clinical Research Achievements<\/p>\n

\n

A UVA researcher\u2019s pioneering work in childhood cancer has been honored by the Clinical Research Forum as one of the top 10 clinical research achievements of 2017.
\nDaniel \u201cTrey\u201d Lee, MD, Assistant Professor of Pediatrics, has been developing a new gene therapy to battle treatment-resistant leukemia in children and young adults. Known as chimeric antigen receptor (CAR) T-cell therapy, the approach genetically modifies a patient\u2019s own immune cells to identify and kill cancer cells.<\/p>\n

\u201cSo many excellent, high-impact clinical trials are performed every year. To have our work chosen as one of the top 10 in the country is an incredible honor. I am so grateful for our incredible team of investigators, without whom we wouldn\u2019t have such an impact on kids with cancer,\u201d Lee said. \u201cOur results have paved the way for combination CAR T-cell therapies in leukemia, aimed at overcoming one of CAR therapy\u2019s major obstacles \u2013 tumors changing their proteins to escape CAR T cells. That we are pioneering this in children, before adults, is amazing.\u201d<\/p>\n

Read more: https:\/\/newsroom.uvahealth.com\/\u2026\/pediatric-oncologist-honor\u2026<\/a><\/p>\n

\u2022 Cancer-causing Virus Discovery Could Lead to Cures for HPV, Other Viruses<\/p>\n

Using a homemade, high-tech microscope, scientists at the School of Medicine have revealed how a cancer-causing virus anchors itself to our DNA. That discovery could pave the way for doctors to cure incurable diseases by flushing out viruses, including HPV and Epstein-Barr, that now permanently embed themselves in our cells.<\/p>\n

\u201cThe reason we can\u2019t get rid of these [viruses] is because we can\u2019t figure out a way to get their DNA out of the nucleus, out of the cell,\u201d explained UVA researcher Dean H. Kedes, MD, PhD, Professor of Microbiology, Immunology, and Cancer Biology. \u201cThey depend on this \u2018tether\u2019 to remain anchored to the DNA within our cells, and to remain attached even as the cells divide. This tether is a key factor to disrupt in devising a cure.\u201d<\/p>\n

Now that scientists can understand this vital infrastructure, they can work to disassemble it. \u201cWithout it,\u201d Kedes noted, \u201cthe virus is going to lose its hold in the body. \u2026 Bad for the virus, but very good for the patient.\u201d<\/p>\n

The findings have been published in Proceedings of the National Academy of Sciences.<\/p>\n

In addition to Kedes, the following UVA SOM members contributed to the study:
\n– M. Mitchell Smith, PhD, Professor of Microbiology, Immunology, and Cancer Biology
\n– Graduate student Margaret Grant
\n– Lab specialist Matthew Loftus<\/p>\n

Read more: https:\/\/newsroom.uvahealth.com\/\u2026\/uva-reveals-how-a-cancer-\u2026\/<\/a>
\n—
\nDid we miss something? If you have UVA SOM faculty news to share, please email christa@virginia.edu.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

UVA SOM Faculty News Weekly Round-Up April 20, 2018 \u2022 UVA Pediatric Oncologist Honored on Top 10 List of Clinical Research Achievements A UVA researcher\u2019s pioneering work in childhood cancer has been honored by the Clinical Research Forum as one of the top 10 clinical research achievements of 2017. Daniel \u201cTrey\u201d Lee, MD, Assistant Professor […]<\/p>\n","protected":false},"author":216,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[10,4],"tags":[],"class_list":["post-942","post","type-post","status-publish","format-standard","hentry","category-faculty-news-weekly-round-up","category-news"],"acf":false,"yoast_head":"\nUVA SOM Faculty News Weekly Round-Up: April 20, 2018 - Faculty Development Blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/news.med.virginia.edu\/fac-dev-blog\/2018\/04\/20\/uva-som-faculty-news-weekly-round-up-april-20-2018\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"UVA SOM Faculty News Weekly Round-Up: April 20, 2018 - Faculty Development Blog\" \/>\n<meta property=\"og:description\" content=\"UVA SOM Faculty News Weekly Round-Up April 20, 2018 \u2022 UVA Pediatric Oncologist Honored on Top 10 List of Clinical Research Achievements A UVA researcher\u2019s pioneering work in childhood cancer has been honored by the Clinical Research Forum as one of the top 10 clinical research achievements of 2017. 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