Department of Defense – Precision Trauma Care Research Award FY18

FY18 Joint Program Committee-6/Combat Casualty Care Research Program (JPC-6/CCCRP)
Precision Trauma Care Research Award

Detailed descriptions of the funding opportunity, evaluation criteria, and submission requirements can be found in the Program Announcement, accessible at http://cdmrp.army.mil/funding/pa/18dmrdpptcra_pa.pdf.

Focus areas for this program.

Neurotrauma For studies proposing animal research, only proposals collecting data from gyrencephalic animal models of traumatic brain injury (TBI) will be considered for funding.

Focus Area 1:  Improving the Characterization of TBI

  • Identification and/or characterization of TBI biomarkers that are specific to TBI alone and/or TBI with concomitant injuries (e.g., burn, hemorrhage) and identification of biomarker profile specific to TBI pathology and treatment effectiveness
  • Development of targeted therapies, devices, or clinical guidelines to improve diagnosis/stabilization/treatment of TBI casualties with and without concomitant polytrauma based upon the precise characterization and individualized assessment of affected domains
  • Improve TBI treatment decision capabilities based upon the precise characterization and individualized assessment of TBI pathology (e.g., contusion, diffuse axonal injury, subdural hematoma, epidural hematoma)
  • Improve the understanding of risk factors and outcomes associated with specific brain pathology (e.g., contusions, diffuse axonal injury, hematomas) with the end state goal of improving prognosis and optimizing recovery
  • Improve the understanding of the role of genetic factors and/or physiology status on short- and long-term consequences of combat-related TBI

Focus Area 2: Understanding the factors that influence and/or inform patient responsiveness to TBI therapeutic interventions

  • Pharmacodynamic characterization of therapeutics with respect to patients responsive to treatment
  • Targeting therapeutics to the blood-brain barrier in response to specific brain injuries (e.g., contusions, diffuse axonal injury, subdural hematoma, epidural hematoma)
  • Understanding the impact of sex-associated differences on the efficacy of TBI treatments
  • Understanding the potential role of genetics and sex-associated differences in TBI treatment decisions and TBI treatment response
  • Identification of biomarkers of TBI that inform treatment effectiveness and stage of recovery
  • Identify the impact of environmental factors (such as altitude, vibration, and/or temperature) that negatively affect TBI outcomes. Identify potential treatments and/or interventions to mitigate these effects

Forward Surgical, En Route, and Critical Care

Focus Area 3: Understanding the role of environmental and physiological factors impacting injury outcomes:

  • Environmental, physiological, and physical factors that govern an individual’s predisposition to various responses to trauma
  • Physiological, genetic, or physical factors that govern the individual’s response to blood loss (ability to compensate for blood loss)
  • Impact of vascular disruption, repair, extremity ischemia and reperfusion, and its relationship to long-term limb recovery and function
  • Determination of more effective and efficient ways to diagnose and manage vascular disruption (with or without hemorrhagic shock) in forward surgical and limitedresource critical care environments

Focus Area 4: Developing materiel and knowledge products to assist medical and nonmedical care providers in administering individualized combat-related or trauma-induced injury care such as:

  • Standardized, clinically relevant decision support model for severely mangled extremities (i.e., decisions regarding primary amputation vs. pursuit of limb salvage, optimal amputation level to support future treatment (i.e., transplant, prosthetic, etc.)
  • Computational algorithms and predictive tools for physiological status monitoring that use available information and can predict necessary statuses in an expedient manner
  • Evidence-based clinical decision support tools/protocols for the prehospital environment and throughout the continuum of care to include en route care (patient medical transport) and timing of transport (particularly for strategic air movement) for post-surgical patients
  • Non-invasive physiological monitoring for compartment syndrome
  • Innovative patient-centered technologies to maintain physiological equilibrium (homeostasis) such as dynamically responsive closed-loop technologies for oxygenation, core temperature maintenance, and medication delivery in the prehospital environment and throughout the continuum of care, to include en route care (patient medical transport)

Submission is a two-step process requiring both (1) pre-application submission through the electronic Biomedical Research Application Portal (eBRAP) (https://eBRAP.org/) and (2) application submission through Grants.gov (http://www.grants.gov/).  Refer to the General Application Instructions, Section II.A. for registration and submission requirements for eBRAP and Grants.gov.

Pre-application deadline:  5:00 pm, March 17, 2017