NIH – HEAL Initiative: Translating Research to Practice to End the Overdose Crisis (R33 Clinical Trial Optional)

August 19, 2022 by


The goal of this initiative is to support action-oriented research that accelerates the translation of research to practice to address the overdose crisis. There remains an urgent need for research that advances the design of stigma-free patient-centered systems of care such that people who experience addiction can recover and sustain their recovery over the long-term. This Funding Opportunity Announcement (FOA) solicits applications that address understudied areas of opportunity, particularly those that focus on fundamental barriers or facilitators to reducing overdose deaths at the individual, provider, organizational, community, or system levels. Projects should be in alignment with the overall goals of the HEAL Initiative, and should focus on replicable, scalable, equitable approaches for accelerating the movement of moving evidence-based and promising treatments into routine use. This FOA invites projects for which preliminary or feasibility data is available. This FOA is a companion to RFA-DA-23-053, which solicits applications for which pilot data is unavailable.


In the 12-month period ending in April 2021, more than 100,000 people lost their lives to overdose deaths. Deaths have continued to rise despite significant efforts and resources aimed at reversing these trends. Research funded through the National Institutes of Health offers numerous promising approaches to responding to this entrenched public health crisis. However, research does not always readily translate to practice. To turn the tide on the overdose crisis, research is needed to address the systemic issues necessary to accelerate the translation of promising research findings to practice.

This FOA is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed the development and implementation of scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative will bolster research across NIH to (1) improve treatment for opioid misuse and addiction and (2) enhance pain management. More information and periodic updates about the HEAL Initiative are available at:

Key Dates:

Open Date (Earliest Submission Date): October 14, 2022
Letter of Intent Due Date(s): 30 days prior to each application due date.
Earliest Application: November 14, 2022

URL for more information:

Filed Under: Funding Opportunities