NIH – HEAL Initiative: HEAL Data2Action Research Adoption Support Center (U2C Clinical Trial Optional) Activity Code

January 14, 2022 by


As part of the NIH HEAL Initiative, the National Institute on Drug Abuse (NIDA) is releasing a set of interrelated RFAs to create the HEAL Data2Action (HD2A) Program, a coordinated effort to promote the synthesis and real-world application of existing data to guide and monitor improvements in service delivery to prevent or treat opioid use disorder (OUD) and pain. Collectively, these projects will address gaps in the delivery of evidence-based practices in each of the four pillars of the HHS Overdose Prevention Strategy: primary prevention, harm reduction, treatment of opioid use disorder, and recovery support. Separate FOAs are being issued to support multiple HEAL D2A Innovation Grants (RFA-DA-22-051); one HEAL D2A Data Infrastructure Support Center (RFA-DA-22-052); one HEAL D2A Research Adoption Support Center (RFA-DA-22-050); and one HEAL D2A Modeling and Economic Resource Center (RFA-DA-22-049). It is imperative that prospective applicants read all of these related FOAs to better understand the intended purpose and structure of the HEAL D2A Program.

This FOA seeks applications for one HEAL D2A Research Adoption Support Center to provide coordination and implementation support for the HEAL D2A Innovation Projects. The Center’s primary purpose is to support funded projects in the selection and adoption of evidence-based practices to address specific service delivery gaps in the areas of substance use prevention and treatment and pain management. The Research Adoption Support Center will also engage key stakeholders, conduct rapid-turnaround research projects addressing barriers to adoption, provide implementation science expertise, and conduct a formative evaluation of the HEAL D2A Program.


In the 12-month period ending in April 2021, more than 100,000 people lost their lives to overdose deaths. Deaths have continued to rise despite significant efforts and resources aimed at reversing these trends. Challenges related to rapidly collecting, interpreting, and using high-quality data to drive decisions and deploy resources in real time represents a major barrier to reversing these trends. The HEAL Data2Action Program is intended to promote real-time use of available data by health systems, communities, and related stakeholders to forecast service delivery needs, identify gaps, and inform proactive response in line with the 4 key pillars of the HHS Overdose Prevention Strategy: primary prevention (including pain management and appropriate opioid prescribing), harm reduction, treatment of opioid use disorder, and recovery support. Multiple Innovation Grants will work independently to identify, merge, and analyze local data to identify or forecast service delivery gaps relevant to addressing the overdose epidemic; select and deploy evidence-based interventions to fill those gaps; and utilize local data to monitor improvements in outcomes along the overdose prevention and opioid care cascade. Three support centers will provide technical assistance and related resources to assist the Innovation Grants in achieving their goals. Applicants to this FOA are strongly encouraged to review the companion FOAs for HEAL D2A Innovation Projects (RFA-DA-22-051), the HEAL D2A Data Infrastructure Support Center (RFA-DA-22-052), and the HEAL D2A Modeling and Economic Resource Center (RFA-DA-22-049) to understand the scope and structure of the HEAL D2A Program.

A visual depiction of the structure and organization of this initiative can be found at:

Key Dates:

Open: February 25, 2022
Letter of Intent Due Date(s): February 25, 2022
Applications Due: February 25, 2022

URL for more information:

Filed Under: Funding Opportunities