NIH – Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)

December 17, 2021 by


An essential element of the mission of NHGRI is to support talented researchers early in their careers, clearing a path for them to drive innovation at the forefront of the field of genomics. NHGRI is committed to the NIH Next Generation Researchers Initiative, which aims to promote the growth, stability, and diversity of the biomedical workforce through a focus on early career stages. This Funding Opportunity Announcement (FOA) is intended to support early career researchers as they begin to establish a vibrant, independent research program in genomics. For the purposes of this FOA, the term “genomics” encompasses issues and activities in all of the foundational areas of research that are of interest to NHGRI, as outlined in the NHGRI Strategic Vision.


This program is aimed at supporting genomics researchers who are early in their independent research career. Consistent with this, applicants must have Early Stage Investigator (ESI) status as defined by the NIH. NHGRI is committed to building a diverse community of genomics researchers, and welcomes applications from early stage investigators with a long-term interest in pursuing genomics research, including individuals from groups typically underrepresented in biomedical research, individuals at institutions that have not traditionally received significant funding from NHGRI, and individuals who have not previously been involved in NHGRI consortia.

Applicants must propose a defined research project that is responsive to the mission of NHGRI. This includes the development of resources, approaches, and technologies that accelerate and support studies focused on the structure and biology of genomes; the genomics of disease; the implementation and effectiveness of genomic medicine; genomic data science and bioinformatics; and ethical, legal, and social issues related to genomic advances. More information about NHGRI’s vision and priority areas can be found in the NHGRI 2020 Strategic Vision and on the web pages for the NHGRI Division of Genome SciencesDivision of Genomic Medicine, and Division of Genomics and Society.

Applicants are strongly encouraged to discuss planned applications with the listed Scientific Contact for this RFA, in order to ensure that their proposed research meets the goals of this program, and is scientifically within the mission of NHGRI. Examples of research that would not be appropriate include, but are not limited to: the use of genomic approaches to understand a specific disease or limited set of diseases, including projects that focus on tumor or somatic cancer genomes; research focused on understanding the mechanisms underlying disease or other biological processes; the development of technologies or approaches that target a limited subset of loci or genomic regions. Applications that fall outside of the mission of NHGRI will be considered non-responsive to this announcement and will not proceed to review.

An important goal of this program is the career development of outstanding, early stage investigators in genomics. In addition to a detailed experimental plan, applicants must include a plan for professional and scientific activities which includes engaging an advisory committee to provide feedback on the research program and offer career guidance, commitment from the institution to actively support the research program development of the Principal Investigator, and additional career enhancement activities as appropriate. See Section IV.2 for detailed application instructions.

See Section VIII. Other Information for award authorities and regulations.

Key Dates:

Open Date (Earliest Submission Date): February 04, 2022
Letter of Intent Due Date(s): February 4, 2022
Earliest Application Due: March, 4, 2022

URL for more information:

Filed Under: Funding Opportunities