NIH – Risk and Protective Factors of Family Health and Family Level Interventions (R01 – Clinical Trial Optional)

December 23, 2021 by


The purpose of this initiative is to advance the science of minority health and health disparities by supporting research on family health and well-being and resilience. The NIMHD Research Framework recognizes family health, family well-being, and family resilience as critically important areas of research to decrease disparities and promote equity.


The overarching purpose of this funding opportunity announcement is to solicit innovative multidisciplinary minority health and health disparities research and interventions at the interpersonal level, especially within and at the family level.

While the NIMHD Research Framework identifies interpersonal level factors as one of several levels contributing to minority health and health disparities, the majority of NIMHD supported research is located at the individual level. Interpersonal level research studies often focus on health risks and protective factors and health outcomes associated with specific dyads (i.e., parent-child, patient-physician), family environment and experiences (i.e., adverse childhood experiences, sibling, and peer relationships), and across healthcare settings (i.e., family roles in care giving, care management, and health-care related decision making). Research on patient populations has centered on the health of the individual or patient level focusing on their condition and treatment or their risk and resilience while ignoring the health and well-being of other family members and the overall health of the family unit. Outside the caregiving and family studies literature, few studies explore the interaction of family level risk and protective factors (functioning, cohesion or resilience) or family level factors associated with family health outcome measures, such as family well-being, family health behaviors (nutritional practices, health beliefs and practices, physical activity/exercise, preventive screenings, healthcare utilization, or health outcomes). Research is lacking on how, when, and why families leverage various resources at the neighborhood, community, organizational or health services levels, and how technology or other resources have been leveraged to promote and protect family health or prevent or mitigate internal and external threats to family health or the health of family members.

For the purpose of this funding opportunity, the following definitions are listed below:

Family: two or more individuals, of any gender or who identify with more than one gender, where one is from a population NIH recognizes as experiencing health disparities. These families share enduring intimate social relationships that may be characterized by blood or legal ties, shared residence, economic cooperation within or across borders, shared responsibilities, and a sense of mutual or collective obligation. This is inclusive of nuclear, extended, blended, adopted, foster, and chosen families. We recognize that researchers may define family unit differently and thus responsive applications will either use this definition or clearly define the term within the context of the proposed research.

Family level: encompassing collective measures of family health behaviors and processes or pathways or performing interventions with multiple family members. Applications not including family health measures (i.e., not including health outcome measures for 2 or more family members) or family level research (i.e., not including family level health behaviors or processes) will be considered non-responsive.

Key Dates:

Open Date (Earliest Submission Date): May 05, 2022
Letter of Intent Due Date(s): Not Applicable
Earliest Applications Due: June 05, 2022

URL for more information:

Filed Under: Funding Opportunities