The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for a Regional Prospective Observational Research in Tuberculosis (RePORT) International Coordinating Center (RICC) for the national RePORT networks, whose mission is to advance regional and international TB and TB/HIV science, strengthen TB/HIV research capacity and infrastructure, and foster research collaboration. The RICC will coordinate the planning and implementation of research in TB and TB/HIV across all the RePORT Networks to ultimately improve health outcomes for persons with TB and TB/HIV.
TB is among the leading infectious disease killers, especially for persons with HIV (PWH). The World Health Organization (WHO) reported that an estimated 10 million people fell ill with TB, and about 1.4 million died in 2019; 200,000 of those deaths were among PWH. These numbers make TB the most significant cause of mortality among PWH and place TB in the top 10 causes of death globally.
Despite current research investments by various funding entities and recent research advances, the tools and strategies needed to bring the scourge of TB among PWH to an end are not yet available or accessible to many populations. Effective vaccines, true point‐of‐care diagnostics, simpler treatment regimens and strategies to improve case finding and treatment retention are within reach but require a collaborative, global research effort to achieve.
RePORT International is a global consortium of six member countries (Brazil, China, India, Indonesia, Philippines, and South Africa). Each national RePORT network operates independently to advance research of priority to the host nation and the network investigators. Additionally, as opportunities arise, various national networks collaborate with one another and other external partners to advance research of global interest.
RePORT networks have been successful in advancing seminal and high priority research in both the clinical and laboratory setting. RePORT networks across the world are now following long-term TB/HIV cohorts and generating substantive research outputs. A centralized research coordinating center is needed to enable coordination of trans-network, internal and external research projects.
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