The purpose of this Funding Opportunity Announcement (FOA) is to encourage research addressing major gaps identified in the United States Preventive Services Task Force (USPSTF) recommendation statement concerning interventions to prevent perinatal depression, with an emphasis on populations experiencing mental health disparities. The research scope for this FOA includes: 1) strategies for identifying women at risk for perinatal depression; 2) developing and testing tools for selecting those most likely to benefit from preventive interventions; 3) testing service-ready efficacious preventive interventions that are of appropriate intensity/dose, and are scalable, such that they can be delivered with fidelity by setting providers; and, 4) testing strategies that can be used to train providers and to support delivery of evidence-based approaches with fidelity across diverse health care and community settings.
This FOA is intended to support effectiveness research trials that are statistically powered to provide a definitive answer regarding the effectiveness of the intervention. Support for pilot effectiveness is provided via a companion R34 FOA (RFA-MH-21-241) that supports pilot effectiveness studies in preparation for the larger-scale, fully powered studies described in this FOA.
Perinatal depression is one of the most common complications of pregnancy and the postpartum period. It affects as many as 1 in 7 pregnant women and can result in negative short- and long-term consequences for mother and baby. In 2019, the USPSTF concluded that providing or referring pregnant or postpartum women who are at increased risk to cognitive behavioral therapy (CBT) or interpersonal therapy (IPT) has a moderate net benefit in preventing perinatal depression. Hybrid effectiveness-intervention trials are needed to understand better how these and other research-supported interventions may be implemented at scale in diverse healthcare and community settings by local providers who are trained to deliver interventions with fidelity.
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Filed Under: Funding Opportunities