Enduring Hearts – Heart Transplant Longevity

July 30, 2021 by dld5dt@virginia.edu

Grant Opportunity: Enduring Hearts’ Scientific Advisory Committee seeks to fund projects up to 2 years that have a combination of the best science, innovation, and potential for clinical impact. Specific areas of research requested for the current proposal include:

➢ Improving longevity and quality of post-heart transplant life by reducing/eliminating rejection and Cardiac Allograft Vasculopathy (CAV) by:
○ Integrating accurate non-invasive surveillance methods, technologies, and biomarkers for care strategies, technologies, and methods towards EARLIER identification of the onset of acute cellular rejection (ACR), antibody-mediated rejection (AMR), and/or cardiac allograft vasculopathy (CAV)
○ Development of therapeutics and/or therapeutic strategies for acute cellular rejection (ACR), antibody-mediated rejection (AMR), and/or cardiac allograft vasculopathy (CAV)
○ Developing novel immunotherapies, identification of novel targets for immunosuppression, improving methods for monitoring and determining the optimal level of immunosuppression to prevent ACR, AMR, and/or CAV while reducing/eliminating secondary conditions that may arise due to immunosuppression (renal; infectious)
○ Development and validation of better experimental models to study the underlying mechanisms, therapies, and/or prevention of CAV

➢ Development of evidence-based strategies to improve the longevity of adolescent recipients including:
○ Improving transition from pediatric to adult care/medication adherence
○ Development of evidence-based tools for improving pediatric heart recipient and family education related to heart transplantation
○ Improving evidence-based diverse psycho-social support methods including technologies, hosted peer action groups, virtual visit models, and remote metrics

➢ Strengthen pre-transplant strategies, innovations, or new technologies for children waiting for and immediately after receiving a heart transplant including:
○ Applying advanced data analytics to better integrate extracardiac and cardiovascular candidate risk factors including the degree of multiorgan dysfunction and frailty, race       and ethnic group, and HLA and non-HLA sensitization
○ Innovative strategies that would improve organ availability, matching, utilization, and allocation
○ Pre-transplant modifications in donor heart immunogenicity
○ Promotion of evidence-based optimization and standardization of pre-transplant protocols including donor selection and management
○ Pediatric scaled xenotransplantation and/or tissue engineering

Full Proposal Deadline:  8/15/21
Grant Funding:  Grants with a budget range of $25,000-$150,000 will be considered.
For information, https://enduringhearts.org/wp-content/uploads/2021/06/EH-Direct-Grant-FAQ-update-2021.pdf
For questions, please contact:  grants@enduringhearts.org


Filed Under: Funding Opportunities