NIH – Social and Behavioral Intervention Research to Address Modifiable Risk Factors for Cancer in Rural Populations (R01 Clinical Trial Required)

September 25, 2020 by


The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications to develop, adapt, and test individual-, community- or multilevel interventions to address modifiable risk factors for cancer in rural populations. Applications should focus on primary prevention and assess and address one or more of the social and behavioral risk factors that contribute to cancer disparities in rural populations: tobacco use; diet, physical activity and weight; alcohol use; UV exposure; and HPV vaccination. Applications should also assess and address myriad social determinants of health, cultural factors, and health care and technology access barriers that may contribute to rural cancer disparities. This FOA also encourages implementation science research, to incorporate efficacious cancer control interventions in a coordinated way, into broader, sustainable health programs that are designed to reach rural populations and allow local customization and adaptation.


There is substantial geographic variation in cancer risk factors, incidence, and mortality in the United States (US). Estimates of the total population living in non-metropolitan (rural) counties in the United States vary from 46.2 million to 59 million people, compared to more than 250 million people living in urban areas; this represents 14-19% of the US population. Rural populations face elevated rates of disease-related morbidity and mortality, as well as greater percentages of potentially excess deaths from the five leading causes of death, including cancer. Individuals in rural counties have an 8% higher overall cancer mortality than those in urban areas, and a rural-urban disparity in mortality has been observed for lung, colorectal, prostate, and cervical cancers. Recent studies using different cancer registries and different approaches to defining rural geographic areas report similar elevated cancer incidence rates in rural areas for many preventable cancers, including lung, cervical, colorectal, oropharyngeal, and melanoma. Intervention research focused on primary prevention of cancer is needed in rural areas.

Key Dates:

Open Date (Earliest Submission Date): February 15, 2021
Letter of Intent Due Date(s): 30 days prior to the application due date
Application Due Date(s): March 15, 2021; January 18, 2022

URL for more information:

Filed Under: Funding Opportunities