NIH – Mechanistic Studies of the Interaction between SARS-CoV-2/COVID-19 and Diseases and Organ Systems of Interest to NIDDK (R01 Clinical Trial Optional)

July 17, 2020 by


The purpose of this Funding Opportunity Announcement (FOA) is to support basic and clinical mechanistic research on Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19) susceptibility, routes of infection, course of disease, morbidity and mortality in people with pre-existing diseases, or adverse acute or chronic outcomes in organs, tissues, and biological systems of specific interest to NIDDK. These include diabetes and other metabolic diseases, obesity, and endocrine, digestive, liver, pancreas, kidney, urological, and hematologic tissues and diseases.


Patients with many underlying diseases and conditions are at increased risk of acquiring and having adverse outcomes from SARS-CoV-2 infection. In addition, emerging evidence suggests that many organs are targeted by this virus, which contributes significantly to COVID-19 morbidity and leads to organ-specific complications after recovery from infection. NIDDK is interested in diabetes and other metabolic diseases, obesity, and endocrine, digestive, hepatobiliary, pancreas, kidney, urological and hematologic tissues and diseases. Mechanistic understanding of the ways that SARS-CoV-2 infects and affects these organs and systems, including individual susceptibility to infection and acute and long-term sequalae of COVID-19, are largely unknown. Investigations of those mechanisms are expected to contribute to additional strategies for management of SARS-CoV-2 infected individuals with concurrent diseases and conditions or new organ- or system-specific sequalae of infection.

Key Dates:

Open Date (Earliest Submission Date): November 16, 2020
Letter of Intent Due Date(s): November 16, 2020
Application Due Date(s): December 16, 2020

URL for more information:

Filed Under: Funding Opportunities