NIH -Patient-oriented Research to Mitigate Health Disparities and Lessen the Burden of Chronic Diseases Within the Mission of NIDDK (R01 Clinical Trial Optional)

March 23, 2020 by


This Funding Opportunity Announcement invites applications to conduct patient-oriented clinical research studies designed to develop strategies to mitigate health disparities in people with one or more chronic diseases or conditions within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Populations of interest include those disproportionately burdened with multiple chronic conditions and/or disparities in social, behavioral and/or biological risk factors. Only studies that involve interaction with human participants will be considered appropriate for this FOA. NIDDK intends to commit $12,000,000 in FY 2020 to fund 2-3 awards.


NIDDK’s research interests include chronic diseases and conditions such as diabetes and other endocrine and metabolic diseases; digestive and liver diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases. Many of these diseases and disorders disproportionately affect the health of underserved populations in the United States. It is recognized that both biologic and non-biologic factors may contribute to the development or progression of diseases of interest to NIDDK for these underserved populations. For the purposes of this FOA, health disparities are defined according to Healthy People 2020 as “a particular type of health difference that is closely linked with social, economic, and/or environmental disadvantage. Health disparities adversely affect groups of people who have systematically experienced greater obstacles to health based on their racial or ethnic group; religion; socioeconomic status; gender; age; mental health; cognitive, sensory, or physical disability; sexual orientation or gender identity; geographic location; or other characteristics historically linked to discrimination or exclusion.”

Research Objectives

Research approaches relevant for this opportunity may include behavioral, clinical, translational, and/or contextual research in representative populations, including differences across the lifespan. Contextual research is inclusive of sociocultural factors, food environment, built environment, workplace, housing, neighborhood, and/or related environmental factors in the context of their influence on health outcomes. Studies should focus on strategies to mitigate health disparities in populations with one or more chronic disease/conditions within the mission of NIDDK. Studies that seek to engage the community stakeholders or seek to integrate medical and social care interventions are particularly encouraged as are studies that propose to identify and overcome barriers to medical care. Transdisciplinary research studies and clinical trials are of particularly high priority.

Key Dates:

Open Date – April 22, 2020
Letter of Intent Due Date(s) – April 22, 2020
Application Due Date(s) – May 22, 2020
URL for more information:

Filed Under: Funding Opportunities