NIH – Collaborative Program Grant for Multidisciplinary Teams (RM1 – Clinical Trial Optional)

February 7, 2020 by


This funding opportunity announcement (FOA) is designed to support highly integrated research teams of three to six PDs/PIs to address ambitious and challenging research questions that are important for the mission of NIGMS and are beyond the scope of one or two investigators. Collaborative program teams are expected to accomplish goals that require considerable synergy and managed team interactions. Project goals should not be achievable with a collection of individual efforts or projects. Teams are encouraged to consider far-reaching objectives that will produce major advances in their fields.

Applications that are mainly focused on the creation, expansion, and/or maintenance of community resources, creation of new technologies, or infrastructure development are not appropriate for this FOA.


Recent reports (e.g., enhancing the effectiveness of team science) have evaluated the benefits of a team science approach to scientific inquiry, and the need to create flexible funding opportunities that enable interdisciplinary research teams to accomplish goals that could not be achieved individually. The Collaborative Program Grant draws on our past experience and is designed to improve support for interdisciplinary collaborative research across different scientific domains. We also anticipate that these grants will enhance the diversity and interdisciplinarity of participating investigators, and provide opportunities to encourage early stage investigators (ESIs) to engage in team science projects. For information on NIGMS’ interest in enhancing diversity of the scientific workforce and support of Early Stage Investigators, see NIGMS Strategic Plan.

Successful Collaborative Program Grant applications will bring together scientists to apply complementary approaches to work on an important and well-defined problem. Applications may address any area of science within the NIGMS mission, which is to support basic research that increases understanding of biological processes at a range of levels, from molecules and cells, to tissues, whole organisms, and populations. NIGMS also supports research in a limited number of clinical areas that affect multiple organ systems. Truly new interdisciplinary ideas for approaching significant biological problems are encouraged. Applications that bridge the research interests of more than one NIGMS division are also encouraged, but must remain within the scope of the NIGMS mission. Research with the overall goal to gain knowledge about a specific organ or organ system, or the pathophysiology, treatment, or cure of a specific disease or condition will, in most cases, be more appropriate for another Institute or Center. Consultation with NIGMS staff (see below) prior to preparing an application is strongly encouraged.

Key Dates

Open Date (Earliest Submission Date) – April 27, 2020
Letter of Intent Due Date(s) – 30 days prior to the application due date
Application Due Date(s) – May 27, 2020; January 27, 2021; May 27, 2021; January 27, 2022; May 27, 2022; January 27, 2023
URL for more information

Filed Under: Funding Opportunities