NIH – Multisite Clinical Center Common Fund Acute to Chronic Pain Signatures Program: Acute Peri-operative Pain or Musculoskeletal Trauma (UM1 Clinical Trial Optional)

September 4, 2019 by


The purpose of this FOA is to support a Multisite Clinical Center to implement the enrollment and multimodal longitudinal assessment of a large cohort of patients that EITHER experienced an acute musculoskeletal trauma OR an acute peri-operative pain event to identify a biosignature for resilience to and/or the transition from acute to chronic pain.


A2CPS is related to the multi-pronged HEAL (Helping to End Addiction Long-term) Initiative, an aggressive effort to speed scientific solutions to stem the national opioid public health crisis ( HEAL will build on extensive, well-established NIH research to address the opioid crisis and provide safer therapies for people with pain. Funding for A2CPS will be from the NIH Common Fund, which supports cross-cutting programs that are expected to have exceptionally high impact. All Common Fund initiatives invite investigators to develop bold, innovative, and often risky approaches to address problems that may seem intractable or to seize new opportunities that offer the potential for rapid progress.

The Office of Strategic Coordination (Common Fund) intends to commit $3.4 million in FY20 – this will include a 6 month preparation period as well as the first year of funds for recruitment, $2.5 million in FY21, and $700K in FY22.

Key Dates:

Posted Date: August 29, 2019
Open Date (Earliest Submission Date): October 25, 2019
Letter of Intent Due Date(s): October 25, 2019
Application Due Date(s): November 26, 2019.

All applications are due by 5:00 PM local time of applicant organization.

Web link for more information:

Filed Under: Funding Opportunities