The National Institute on Drug Abuse (NIDA) is seeking research grant applications which propose the discovery and development of safe and effective medications for the treatment of Substance Use Disorders (SUDs) through the establishment of strategic alliances. That is, leveraging NIDA funds with the expertise and resources of researchers at for profit or non-profit organizations (including, but not limited to, academic institutions, pharmaceutical companies, biotech companies, private or public foundations).
Over the past 20 years, basic research has identified neural substrates and pathways implicated in reward and addiction. However, the application of this basic knowledge to the development of effective medications to treat SUDs has largely been unsuccessful in both preclinical and early clinical stage development, hindered by the costs and high attrition rates of compounds. Later stage clinical development also presents formidable challenges, with prospective SUD medications failing due to lack of efficacy, tolerability and unexpected toxicity, as well as “human” issues such as difficulties in recruitment, medication compliance and subject loss during the trial and prior to follow up.
By providing funds well beyond a traditional research project grant, this Strategic Alliances FOA will accelerate medications development, fostering collaborative ventures of NIDA with other entities such that each makes a significant commitment of resources toward the goal of obtaining FDA approval of safe and effective medications for SUDs. Examples of resources that alliance partners could make include salary support for key study personnel, toxicology and/or analytical assays, providing clinical trial materials, clinical support (e.g., monitoring, site support), and/or statistical analyses.
Application budgets are limited to $3 million per year for direct costs but need to reflect the actual needs of the proposed project.
Posted Date – July 26, 2019
Open Date (Earliest Submission Date) – August 26, 2019
Letter of Intent Due Date(s) – 30 days prior to submission
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Filed Under: Funding Opportunities