NIH – Brain Initiative: Research to Develop and Validate Advanced Human Cell-Based Assays To Model Brain Structure and Function (R01 Clinical Trial Not Allowed)

June 7, 2019 by


This Funding Opportunity Announcement (FOA) encourages research grant applications directed toward developing next-generation human cell-derived assays that replicate complex nervous system architectures and physiology with improved fidelity over current capabilities. This includes technologies that do not rely on the use of human fetal tissue, as described in NOT-OD-19-042. Supported projects will be expected to enable future studies of complex nervous system development, function and aging in healthy and disease states.

Research Objectives:

The purpose of this FOA is to stimulate basic research to develop next-generation human cell-derived assays with improved fidelity to complex human brain, spinal cord, and/or sensory end organ circuit physiology, which will ultimately facilitate analysis of higher order functional deficits relevant to complex nervous system diseases. This FOA is distinct from others that focus on optimization and scalability of assays for compound screening, although projects could, in principle, have utility for late stage evaluation of drug efficacy and toxicity.

Award Budget:
Application budgets are limited to $500,000 in direct costs in any project year and need to reflect the actual needs of the proposed project.

Key Dates:

Open Date (Earliest Submission Date): October 01, 2019
Letter of Intent Due Date(s): October 1, 2019
Application Due Date(s): November 1, 2019 by 5:00 PM local time of applicant organization.

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Filed Under: Featured, Funding Opportunities