NIH/NIDDK – High impact, Interdisciplinary Science in NIDDK Research Areas (RC2 Clinical Trial Optional)

March 12, 2019 by School of Medicine Webmaster

The mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is to conduct and support medical research and research training and to disseminate science-based information on diabetes and other endocrine and metabolic diseases; digestive diseases, nutritional disorders, and obesity; and kidney, urologic, and hematologic diseases, to improve people’s health and quality of life. To that end, the NIDDK, through extramural grants programs of its Programmatic Divisions, supports a broad range of biomedical research.

The purpose of the High Impact, Interdisciplinary Science grants program is to support high impact research that may lay the foundation for new fields of investigation within the mission of NIDDK.   The interdisciplinary approach encouraged by this FOA is envisioned to generate a research resource and/or foster discovery-based or hypothesis-generating science that can have a significant impact on the broader scientific community.    This FOA seeks novel approaches in areas that address specific knowledge gaps, scientific opportunities, new technologies, data generation, or research methods that will advance the area in significant ways designed to accelerate scientific progress in the understanding, treatment and prevention of diseases within the mission of NIDDK.

Scope and Specific Requirements

 RC2 projects should address one or more of the following objectives:

  • Groundbreaking, innovative, high impact and cross-cutting research projects that will improve and accelerate biomedical research.
  • Basic, clinical, and translational projects that could fundamentally enhance the research enterprise and that require the participation, interaction, coordination and integration of activities carried out in multiple research laboratories.
  • Creation of large scale unique resources and/or development of transformative technologies that can benefit a wide range of investigators.
  • High-impact discovery-based and hypothesis-generating science.

RC2 projects are not intended to support:

  • Traditional investigator-initiated, hypothesis-driven and highly focused studies (best supported by the R01 or P01 mechanisms).
  • Research that is a logical extension of ongoing work.
  • Core (or related) services to supplement the budgets of existing R01-type efforts.
  • Applications with a major emphasis outside of the mission of the NIDDK.

Prior Consultation with NIDDK

Consultation with NIDDK staff at least 3 months (and preferably 6 months) prior to the application due date (including resubmission applications) is strongly encouraged for submission of the High Impact, Interdisciplinary Science in NIDDK Research (RC2) application. If requested, NIDDK staff will consider whether the proposed RC2 meets the goals and mission of the Institute; whether it addresses one or more high priority research areas; and whether the application is best fit to the RC2 activity code (or could the proposed work be supported efficiently through traditional NIH funding mechanisms such as a large multi-PI R01?).

NIDDK staff will not evaluate the technical and scientific merit of the proposed project; technical and scientific merit will be determined during peer review using the review criteria indicated in this FOA. During the consultation phase, if the proposed project does not meet NIDDK’s programmatic needs or is not appropriate for this FOA, applicants will be strongly encouraged to consider other Funding Opportunities.

Deadlines:  May 30, 2019; October 31, 2019; June 2, 2020; November 3, 2020; June 1, 2021; November 2, 2021 (letters of intent due six weeks prior to deadline)


Filed Under: Funding Opportunities