The Department of Defense (DOD) Office of Congressionally Directed Medical Research Programs (CDMRP) https://cdmrp.army.mil/pubs/press/press.shtml has released this pre-announcement to allow investigators time to plan and develop ideas for submission to the anticipated FY19 funding opportunities.
The PRORP will solicit research applications that specifically address at least one of the following FY19 Focus Areas:
- Compartment Syndrome Models: Diagnostic and/or treatment strategies developed in a large animal model that replicates compartment syndrome. Model system should be clinically relevant and scientifically reproducible.
- Limb Stabilization and Protection: Development of rapid limb stabilization and novel wound protectants for severely wounded limbs to enable transport at the point of need.
- Retention on Duty Strategies: Development and/or optimization of battlefield-feasible diagnostic capabilities, decision support tools, interventions, and/or rehabilitation strategies that can facilitate retention on duty for common combat-related musculoskeletal injuries. (Biomarker studies are excluded.)
- Skin-implant Interface: Identification of best practices to address infection at the skin-implant interface for osseointegrated prosthetic limbs.
- Translation of Early Findings: Translation of early research findings in orthopaedic surgical care topic areas (volumetric muscle loss, compartment syndrome, and soft tissue trauma) to move the research toward clinical trials and clinical practice.
- Tissue Regeneration Therapeutics: Development of advanced tissue regeneration therapeutics in nerve, muscle, and/or composite tissue for the restoration of traumatically injured extremities (excludes isolated bone tissue engineering studies).
The following FY19 funding opportunities are anticipated:
Applied Research Award
- Independent investigators at all academic levels (or equivalent) are eligible to submit applications.
- Pre-application is required; full application submission is by invitation only.
- Supports applied research applications focused on advancing optimal treatment and restoration of function for military personnel with musculoskeletal injuries sustained during combat or combat-related activities.
- Proposed research should be supported by preliminary data and have the potential to make significant advancements toward clinical translation.
- Clinical trials are not allowed under this award mechanism.
- Applications must address one the following FY19 PRORP Focus Areas: Compartment Syndrome Models; Limb Stabilization and Protection; or Retention on Duty Strategies.
- Maximum funding of $750,000 for total costs (direct plus indirect costs) over a period of 3 years.
Clinical Translational Research Award
- Independent investigators at all academic levels (or equivalent) are eligible to submit applications.
- Pre-application is required; full application submission is by invitation only.
- Supports high-impact and/or emerging research that may or may not be ready for a full-scale, randomized, controlled clinical trial.
- Funding must support clinical research studies involving humans.
- Preliminary or published data relevant to the proposed research project are required.
- Collaboration with military researchers and clinicians is encouraged.
- Investigational New Drug or Investigational Device Exemption applications, if needed, should be submitted to the Food and Drug Administration within 12 months of the award date.
- Applications must address one the following FY19 PRORP Focus Areas: Retention on Duty Strategies; or Tissue Regeneration Therapeutics
- Maximum funding of $2M for total costs over a period of 4 years.
Clinical Trial Award
- Independent investigators at all academic levels (or equivalent) are eligible to submit applications.
- Pre-application is required; full application submission is by invitation only.
- Supports rapid implementation of clinical trials with the potential to have a major impact on military combat-related orthopaedic injuries or non-battle injuries that significantly impact unit readiness and return-to-duty/work rates.
- Funding must support a clinical trial and may not be used for preclinical research studies.
- Collaboration with military researchers and clinicians is encouraged.
- Investigational New Drug or Investigational Device Exemption applications, if needed, should be submitted to the Food and Drug Administration within 6 months of the award date.
- Applications must address one the following FY19 PRORP Focus Areas: Limb Stabilization and Protection; Retention on Duty Strategies; or Translation of Early Findings.
- Applications submitted to the Translation of Early Findings (soft tissue trauma only) Focus Area may elect a Rehabilitation Option, which provides a higher funding maximum for surgical intervention studies that propose an integrative rehabilitation component.
- Maximum funding of $2.5M for total costs ($3M maximum total costs if requesting the Rehabilitation Option) over a period of 4 years.
Descriptions of each of the anticipated funding opportunities, eligibility, key mechanism elements, and funding can be found in the respective Program pre-announcement. FY19 pre-announcements can be found in the CDMRP home page features at https://cdmrp.army.mil.
Subsequent notifications will be posted when the program announcements/funding opportunities are released.
Filed Under: Funding Opportunities