Department of Defense – pre-announcement of Multiple Sclerosis Research Program (MSRP) FY19

March 12, 2019 by School of Medicine Webmaster

DoD has released a pre-announcement for this program, which is managed by the Department of Defense (DOD) office of Congressionally Directed Medical Research Programs (CDMRP) https://cdmrp.army.mil/pubs/press/press, to allow investigators time to plan and develop ideas for submission to the anticipated FY19 funding opportunities.

Applications submitted to the FY19 MSRP must address at least one of the following Focus Areas:

  1. Factors That Promote Central Nervous System Regenerative Potential in Demyelination.  Supports innovative mechanistic studies and translational approaches to promote axonal protection, regeneration, or remyelination in MS and/or relevant experimental models.  Note: Studies addressing the following topics will not be considered for funding: developmental myelination, dysmyelination, blood-brain barrier permeability, basic mechanisms of demyelination, neurodegeneration, or inflammatory mechanisms and anti-inflammatory therapeutic strategies that limit tissue injury secondarily.
  2. Correlates of Disease Activity and Progression in MS.  Supports the identification and/or validation of correlates of disease activity and progression using pre-existing specimens and/or data acquired from well-characterized, adequately controlled, and sufficiently powered patient cohorts.  Note: The study must leverage pre-existing specimens and/or data that are available at the time of application submission; collection of a single set of specimens and/or data collected at one additional time point from participants in the existing cohort is allowed.
  3. Biology and Measurement of MS Symptoms.  Supports studies on the biology and measurement of MS symptoms, which may include pain, fatigue, depression, anxiety, loss of bladder control, impaired mobility, and cognitive, motor, visual, or sexual dysfunction.

FY19 funding opportunities are anticipated for the following programs:

Exploration – Hypothesis Development Award

  • Independent investigators at or above the level of Assistant Professor (or equivalent).
  • Pre-application submission is required; application submission is by invitation only.
  • Supports the initial exploration of innovative, high-risk, high-gain, and potentially groundbreaking concepts in the MS research field.
  • Preliminary data not required.
  • Clinical trials not allowed.
  • Maximum funding of $150,000 for direct costs (plus indirect costs) over a period of 2 years.

Investigator Initiated Research Award

  • Independent investigators at or above the level of Assistant Professor (or equivalent).
  • Pre-application submission is required; application submission is by invitation only.
  • Supports highly rigorous, high-impact research with the potential to make an important contribution to MS research and/or patient care.
  • Preliminary data required.
  • Clinical trials not allowed.
  • Maximum funding of $600,000 for direct costs (plus indirect costs) over a period of 3 years.

Descriptions of each of the anticipated funding opportunities, eligibility, key mechanism elements, and funding can be found in the Program pre-announcement.  FY19 pre-announcements can be found in the CDMRP home page features at https://cdmrp.army.mil.

Deadlines to be announced in the future.

Filed Under: Funding Opportunities