NIH – Alzheimer’s-focused administrative supplements for NIH grants that are not focused on Alzheimer’s disease

December 3, 2018 by School of Medicine Webmaster

The participating Institutes and Centers (ICs) are inviting applications to expand existing awards in these ICs that are not currently focused on Alzheimer’s disease and its related dementias (ADRD) to allow them to develop a focus on ADRD. Active awards with project end dates in FY 2020 or later are eligible. The award may not be in terminal no cost extension or going into no cost extension in FY2019. Please note that a few ICs limit no cost extensions in a non-competing year of an award. For that reason, it is important to contact staff at the Institute supporting the award when planning the duration of the supplement request.

As administrative supplements the work proposed needs to be within the scope of the research or training that is already supported. Center awards and resource awards are most likely to be able to justify these supplements as they tend to have a broad content scope. Some research grants will also qualify if the current research is on a related topic (such as cognitive decline in aging; caregiving; the biology of neurodegeneration; genetics; imaging; computational methods; pain perception; or biostatistical tools that have application to research on Alzheimer’s and its related dementias).

As part of the application, investigators should submit an abstract of the proposed research that shows the relevance to ADRD. The work may include pilot projects or resource development.  In preparing the submission, indicate that it is a response to NOT-AG-18-039 in Field 4.b on the SF 424 form.

Investigators should submit applications as responses to the parent active administrative supplement PA:

Electronic submissions are strongly preferred for this funding opportunity. Use one of the methods described in PA-18-591Electronic submissions allow expedited administration and review of the applications. They allow tracking of applications received and simple movement of applications between Institutes – a requirement for this initiative. The ASSIST system allows most complex awards to submit supplement requests electronically.

Individual requests can be no more than $250,000 in direct costs exclusive of Facilities and Administrative costs on sub-contracts.  Though supplement requests are not limited to one per award, we will consider substantial additional funding to an award as beyond the scope of the funded award.

Requests must be received by February 26, 5:00 p.m. local time of the applicant organization for funding in FY 2019.

Institute-, Center-, and Office-specific Instructions

National Human Genome Research Institute: NHGRI in collaboration with NIA will support supplements to NHGRI grants up to $500,000 direct cost, to support research that accomplishes NIA’s research goals described in this notice. NHGRI will support studies that provide generalizable methods and knowledge in all three scientific areas of genome sciences, genomic medicine and genomics and society. Work proposed in supplements must fall within the scope of the aims of the NHGRI grant to be supplemented.

Investigators are encouraged to contact their NHGRI Scientific Program Officer for the grant to be supplemented before preparing an application, to discuss the relevance of the proposed research to the parent grant and to the Institute’s research priorities.

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD):NICHD is particularly interested in studies that explore the linkages between pregnancy complications such as hypertension and preeclampsia and later development of dementia; the role of head trauma and brain injury in the later development of dementia and the possible benefit of rehabilitation interventions for cognition and gait/balance in AD/ADRD; and in the significantly increased risk of Alzheimer’s disease in adults with Down syndrome.

Review Process

Each IC will conduct administrative reviews of applications from their IC separately. NIA will make funds available for at least ten awards from each of the participating ICs.


  1. Is the work proposed within the scope of the active award?
  2. Is the work proposed focused on Alzheimer’s disease or its related dementias?
  3. Is the work likely to stimulate additional activity leading to progress on ADRD?

Deadlines:  February 26, 2019 (for FY19 funding)


Filed Under: Funding Opportunities