NIH/NIA – Research on Current Topics in Alzheimer’s Disease and Its Related Dementias (R01, R21 Clinical Trial Optional)

November 27, 2018 by School of Medicine Webmaster

The following description was taken from the R01 version of this re-issued FOA.

Alzheimer’s disease (AD) is a progressive, degenerative disorder of the brain and is the most common form of dementia of the elderly. AD is the sixth leading cause of death in the United States. Prominent behavioral manifestations of AD include memory impairments and decline in other cognitive domains. Currently, at least five million Americans at age 65 and older suffer from AD, and it is projected that the number of new cases of AD will double by 2025. AD is clearly becoming a national health crisis affecting Americans across all regions of the country, and the total annual payments of health care for people with AD are projected to be more than $1 trillion in 2050. In response to this looming public health crisis, the National Alzheimer’s Project Act (NAPA) was signed into law in 2011. The primary research goal of the NAPA is to prevent the onset of and develop effective treatments for AD by 2025. As part of the strategic planning process to implement NAPA, NIH AD Research Summits were held in 2012 and 2015 and identified research priorities and strategies needed to accelerate basic research and the development of effective therapies. A FY2017 Alzheimer’s disease bypass budget with milestones was published in 2015 to establish research and funding priorities in response to the NAPA and the AD Research Summits. This funding opportunity announcement was developed in response to the recommendations of the AD Research Summits to support interdisciplinary research to understand the heterogeneity and multifactorial etiology of AD.

Research Objectives

This Funding Opportunity Announcement (FOA) is inviting applications proposing research on current topics in Alzheimer’s disease and its related dementias. Further information on the high-priority topics of interest will be announced through a series of Notices published subsequent to this FOA.

Applications proposing research on topics beyond those specified in the notices will not be prioritized for funding under this FOA. Investigators proposing applications on topics that are not high priority are encouraged to apply to the parent R01 grant or to explore whether their topic would be appropriate for NIA’s other AD-focused FOAs.

Deadlines:  March 11, 2019; July 9, 2019; November 12, 2019; March 11, 2020; July 9, 2020; November 12, 2020; March 11, 2021; July 9, 2021; and November 12, 2021


Filed Under: Funding Opportunities