NIH – Gastrointestinal Mechanisms Contributing to HIV Pathogenesis (R01 Clinical Trial Not Allowed)

June 18, 2018 by School of Medicine Webmaster

This Funding Opportunity Announcement (FOA) seeks interdisciplinary studies, led by Multiple-PD/PI teams, on the effects of Human Immunodeficiency Virus (HIV) or its treatment within the gastrointestinal (GI) tract.  The emphasis is on fundamental mechanisms within the GI tract that impact HIV infection and persistence, GI immune or microbial homeostasis, enteropathy, disease progression, and the development of important comorbidities.  A Multiple PD/PI leadership structure is required. The Multiple PD/PI team must include at least one PD/PI whose expertise is primarily on an aspect of HIV related to the proposed project and at least one PD/PI with appropriate expertise in an aspect of gastrointestinal pathobiology.  The collaboration should provide a more rigorous, thorough, and in-depth evaluation of potential mechanisms than might otherwise be achieved.

Synergistic partnership between Multiple PDs /PIs would benefit several areas where GI biology intersects with HIV infection.  Examples include GI mucosal immunity and HIV-related pathogenesis; the GI mucosal innate and adaptive immune systems and protective immunity to HIV; the impact of HIV infection or its treatment on GI homeostasis; and chronic inflammation, GI epithelial barrier dysfunction, and the development of comorbidities during HIV infection.

Research Objective

Projects submitted to this FOA must use the Multiple PD/PI format and should include at least one PD/PI whose primary expertise is in HIV and at least one PD/PI whose primary expertise is in GI pathobiology. Because this FOA is being issued to address the need to develop greater interaction between the HIV and GI research communities, there is no expectation that teams necessarily have previous publications with each other or otherwise have a history of extensive previous collaboration. The development of the project itself; as reflected in the quality of the preliminary data, the rigor of the approach, and the Multiple PD/PI leadership plan; can provide appropriate evidence of a strong and dedicated Multiple PD/PI team.  Projects that do not have a Multiple PD/PI structure that includes at least one PD/PI whose expertise is primarily on an aspect of HIV related to the proposed project and at least one PD/PI with appropriate expertise in an aspect of gastrointestinal pathobiology will be administratively withdrawn without review.  Studies primarily focused on the liver, gallbladder, pancreas, or non-GI organs will be administratively withdrawn without review.

Topics that might be responsive to this FOA include, but are not limited to:

  • Dysfunctional GI mucosal immunity during HIV infection.
  • Underlying mechanisms of HIV enteropathy and intestinal inflammation. The effects of those processes on GI homeostasis or HIV disease progression.
  • Epithelial cell biology and intestinal barrier dysfunction during HIV infection.
  • Interaction of HIV infection with the gut microbiome, including the effects of HIV on interactions between constituents of the microbial consortium with each other or with the host.
  • HIV infection, transmission, dissemination, and persistence within GI tissues.
  • The impact of HIV treatment on any of the above topics.
Topics that are not responsive to this FOA:
  • Projects that are primarily focused on the immune system outside of the gastrointestinal tract.
  • Studies primarily focused on the consequences of HIV infection or its treatment in the liver, gallbladder, pancreas, or non-GI organs.

Applications that are not compliant and eligible for this FOA (also see Section III):

  • Projects that are not led by a Multiple PD/PI team that includes at least one PD/PI whose expertise is primarily on an aspect of HIV related to the proposed project and at least one PD/PI with appropriate expertise in an aspect of gastrointestinal pathobiology.

Deadline:  February 14, 2019 (letters of intent); March 14, 2019 (full proposals)

URL:  https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-18-009.html

Filed Under: Funding Opportunities