NIH funding opportunities – Oocyte Mitochondrial Function in Relation to Fertility, Aging, and Mitochondrial Diseases

February 5, 2016 by School of Medicine Webmaster

From the R21 version of this FOA:

A major goal of this FOA is to stimulate research that will broaden our understanding of how stage-specific formation and function of mitochondria impact upon the oocyte quality and fertility in women, and on mitochondrial disease transmission to the offspring.

Possible research topics that may be addressed in response to this FOA include, but are not limited to, the following:

  • Mitochondrial function in all aspects of mammalian reproduction including oocyte development and maturation, fertilization, and embryonic development
  • Role of mitochondria in stem cell maintenance and lineage specification in the embryo
  • Assisted reproductive technologies and their impact on mitochondrial function in oocytes and embryos
  • Mitochondrial function in oocytes and embryos during maternal aging
  • Studies on the link between diminished ovarian follicle reserve and mitochondrial function
  • Metabolic disorders and their impact on mitochondrial function in oocytes and embryos
  • Fundamental studies on mitochondrial mutations and their transmission to the offspring, and characterization of mitochondrial diseases
  • Studies on the interaction of nuclear and mitochondrial genomes and its impact on oocyte and fertility, development and disease processes
  • Approaches to enhance mitochondrial function in the oocyte through therapeutic agents
  • Preclinical studies in animal model systems for development of novel procedures for mitochondrial replacement in the oocytes

Deadline:  standard deadlines apply



Filed Under: Funding Opportunities