NOTE: This FOA supports access to specialized specimens rather than research funding.
The NIDDK supports research on topics that encompass some of the most common, severe, and disabling conditions affecting Americans today: endocrine and metabolic diseases such as diabetes and obesity, digestive diseases such as hepatitis and inflammatory bowel disease, kidney and urologic diseases such as kidney failure and prostate enlargement, and blood diseases such as the anemias. Many of the large clinical studies funded by the NIDDK collect biospecimens from subjects for analysis and future study. The collection of these samples from many different studies in the NIDDK Central Repositories has created a valuable resource with which researchers can rapidly validate clinical hypotheses and algorithms for clinical decision-making. The collection is also advancing the development of prognostic variables, biomarkers, and therapeutics for diseases related to the mission of the NIDDK. The Repositories facilitate sharing of NIDDK-supported resources, thus encouraging work by junior investigators, investigators with novel approaches, and others not included in current collaborations, without excluding those who are established in their fields. They help to ensure that research participants make a maximal contribution, and decreases duplicative sampling efforts.
Non-renewable biosamples, such as plasma and urine, and associated data are available from many studies, including the Consortium for Radiological Imaging Studies of Polycystic Kidney Disease (CRISP) and The Study of Viral Resistance to Antiviral Therapy of Chronic Hepatitis C (ViraHep-C), as well as several diabetes studies such as the Type 1 Diabetes Prevention Trial- 1(DPT-1), Diabetes Prevention Program Type 2 Diabetes (DPP), and Diabetes Control and Complications Trial / Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC). A complete list of available samples can be found at https://www.niddkrepository.org/search/study/.
Applicants are required to contact the NIDDK Central Repositories in advance to determine whether there is sufficient quantity of the samples that will be required for the proposed study and to provide that information as part of the application. In addition, applicants must consult with the Repositories to determine whether the proposed use of samples is consistent with the limitations of the subjects’ informed consents.
Deadlines: three per federal fiscal year through 2017, beginning October 30, 2014